Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the
ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS …

Modern vaccine design has sought a minimalization approach, moving to the isolation of
antigens from pathogens that invoke a strong neutralizing immune response. This approach …

To date, vaccination has become one of the most effective strategies to control and reduce
infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were …

Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Proteins span an extraordinary range of shapes, sizes and functionalities. Therefore generic
approaches are needed to overcome this diversity and stream-line protein analysis or …

Nanoscale organization is crucial to stimulating an immune response. Using self-
assembling proteins as multimerization platforms provides a safe and immunogenic system …

Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

The rapid development of a SARS-CoV-2 vaccine is a global priority. Here, we develop two
capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of …