Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

Recently, understanding of the extracellular matrix (ECM) has expanded rapidly due to the
accessibility of cellular and molecular techniques and the growing potential and value for …

Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …

Designing of biologically active scaffolds with optimal characteristics is one of the key factors
for successful tissue engineering. Recently, hydrogels have received a considerable interest …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

This review outlines the new developments on chitosan-based bioapplications. Over the last
decade, functional biomaterials research has developed new drug delivery systems and …

Additive manufacturing techniques offer the potential to fabricate organized tissue constructs
to repair or replace damaged or diseased human tissues and organs. Using these …

The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …

Hydrogels are high-water content materials prepared from cross-linked polymers that are
able to provide sustained, local delivery of a variety of therapeutic agents. Use of the natural …