Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Although dementia has been described in ancient texts over many centuries (eg,“Be kind to
your father, even if his mind fail him.”–Old Testament: Sirach 3: 12), our knowledge of its …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …

In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …

Pathological tau aggregates occur in Alzheimer's disease (AD) and other
neurodegenerative tauopathies. It is not clearly understood why tauopathies vary greatly in …

Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases,
including Alzheimer's disease (AD). Cell culture and animal studies showed that tau fibrils …

Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …

Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …