Brain microvascular endothelial cells form the interface between nervous tissue and
circulating blood, and regulate central nervous system homeostasis. Brain microvascular …

The NO-cGMP signal transduction pathway plays a crucial role in tone regulation in hepatic
sinusoids and peripheral blood vessels. In a cirrhotic liver, the key enzymes endothelial NO …

Background. Ischemic stroke is a severe acute cerebrovascular disease which can be
improved with neuroprotective therapies at an early stage. However, due to the lack of …

Liver microcirculation plays an essential role in the progression and aggravation of chronic
liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver …

Abnormal angiogenesis is critical for portal hypertension in cirrhosis. Except for etiological
treatment, no efficient medication or regime has been explored to treat the early stage of …

BACKGROUND Acute esophageal variceal hemorrhage (AEVH) is a common complication
of cirrhosis and might precipitate multi-organ failure, causing acute-on-chronic liver failure …

In recent years, defined progress has been made in understanding the mechanisms of
hemodynamic disturbances occurring in liver cirrhosis, which are based on portal …

Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal
hypertension results in various vascular alterations. The systemic hemodynamic state in …

Liver cirrhosis is a frequent condition with high impact on patients' life expectancy and health
care systems. Cirrhotic portal hypertension (PH) gradually develops with deteriorating liver …

Introduction: Counteracting splanchnic vasodilatation and increased portal-collateral blood
flow has been the mainstay for the treatment of portal hypertension (PH) over the past three …