[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
TRP channels
K Venkatachalam, C Montell - Annu. Rev. Biochem., 2007 - annualreviews.org
Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …
remarkable in that it displays greater diversity in activation mechanisms and selectivities …
Transient receptor potential (TRP) channels: a clinical perspective
Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
LJ Macpherson, AE Dubin, MJ Evans, F Marr… - Nature, 2007 - nature.com
The nervous system senses peripheral damage through nociceptive neurons that transmit a
pain signal,. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion …
pain signal,. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion …
The functions of TRPA1 and TRPV1: moving away from sensory nerves
ES Fernandes, MA Fernandes… - British journal of …, 2012 - Wiley Online Library
The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …
channels are members of the TRP superfamily of structurally related, non‐selective cation …
Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field
MM Moran, A Szallasi - British journal of pharmacology, 2018 - Wiley Online Library
Control of chronic pain is frequently inadequate and/or associated with intolerable adverse
effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly …
effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly …
Monoterpenes with analgesic activity—a systematic review
AG Guimarães, JSS Quintans… - Phytotherapy …, 2013 - Wiley Online Library
There is still the need for efficacious therapies for pain. In the search for new therapeutic
options, plants are a major source of novel biomolecules. Monoterpenes constitute 90% of …
options, plants are a major source of novel biomolecules. Monoterpenes constitute 90% of …
TRP channels as potential drug targets
MM Moran - Annual review of pharmacology and toxicology, 2018 - annualreviews.org
The transient receptor potential (TRP) superfamily of channels comprises a diverse group of
cation channels. Four TRP channel subunits coassemble to form functional homo-or …
cation channels. Four TRP channel subunits coassemble to form functional homo-or …
Plant volatiles: production, function and pharmacology
Covering: 1989 to February 2011 Plant volatiles typically occur as a complex mixture of low-
molecular weight lipophilic compounds derived from different biosynthetic pathways, and …
molecular weight lipophilic compounds derived from different biosynthetic pathways, and …