Ageing with HIV: Challenges and biomarkers

B Rodes, J Cadinanos, A Esteban-Cantos… - …, 2022 - thelancet.com
The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the
prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease …

Monocytes in HIV and SIV infection and aging: implications for inflamm-aging and accelerated aging

ZK Wallis, KC Williams - Viruses, 2022 - mdpi.com
Before the antiretroviral therapy (ART) era, people living with HIV (PLWH) experienced
complications due to AIDS more so than aging. With ART and the extended lifespan of …

Biological ageing with HIV infection: evaluating the geroscience hypothesis

M Montano, KK Oursler, K Xu, YV Sun… - The Lancet Healthy …, 2022 - thelancet.com
Although people with HIV are living longer, as they age they remain disproportionately
burdened with multimorbidity that is exacerbated in resource-poor settings. The geroscience …

Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individuals

PP Sanna, Y Fu, E Masliah, C Lefebvre… - Scientific reports, 2021 - nature.com
To generate new mechanistic hypotheses on the pathogenesis and disease progression of
neuroHIV and identify novel therapeutic targets to improve neuropsychological function in …

Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression

BK Titanji, M Gwinn, VC Marconi, YV Sun - Clinical Epigenetics, 2022 - Springer
Despite significant advances in the treatment and care of people with HIV (PWH), several
challenges remain in our understanding of disease pathogenesis to improve patient care …

Update in human immunodeficiency virus and aging

JR Faulhaber, AW Baffoe-Bonnie… - Infectious Disease …, 2023 - id.theclinics.com
Over the last 40 years, the journey of people with human immunodefiency virus (HIV)(PWH)
has moved a long way from a near-certain mortality resulting from destruction of the immune …

Urine cell-free mitochondrial DNA as a marker of weight loss and body composition in older adults with HIV

CD Johnston, EL Siegler, MC Rice… - JAIDS Journal of …, 2021 - journals.lww.com
Background: Older adults with HIV (OAH) experience more comorbidities and geriatric
syndromes than their HIV-negative peers, perhaps because of chronic inflammation. Cell …

Plasma cell-free mitochondrial DNA as a marker of geriatric syndromes in older adults with HIV

CD Johnston, EL Siegler, MC Rice… - JAIDS Journal of …, 2022 - journals.lww.com
Background: Older people with HIV (PWH) experience more comorbidities and geriatric
syndromes than their HIV-negative peers, perhaps due to residual inflammation despite …

Mitochondria and human immunodeficiency virus: a troubled relationship enters its fourth decade

T Hulgan, DC Samuels - Clinical Infectious Diseases, 2021 - academic.oup.com
Since antiretroviral therapy (ART) was introduced for treatment of human immunodeficiency
virus (HIV) infection, mitochondria have featured prominently in the landscape of HIV clinical …

Mitochondrial DNA Profiling in A Cohort of Antiretroviral Treated HIV Patients in Lagos, Nigeria: Assessment of Long-Term Effects of cART on Life Quality of PLWH

AP Okwuraiwe, RA Ahmed, D Tajudeen… - European Journal of …, 2022 - ej-med.org
The use of combined antiretroviral therapy (cART) has turned HIV infection to a manageable
condition, significantly reducing HIV-related morbidity and mortality globally. Risk of …