Advances in biosensors and diagnostic technologies using nanostructures and nanomaterials

EC Welch, JM Powell, TB Clevinger… - Advanced Functional …, 2021 - Wiley Online Library
Nanoscale materials have unique properties that make them especially useful for
biomedical diagnostic applications. Recent developments in nanoengineering have resulted …

Cell-based biosensors: Recent trends, challenges and future perspectives

N Gupta, V Renugopalakrishnan, D Liepmann… - Biosensors and …, 2019 - Elsevier
Existing at the interface of biology and electronics, living cells have been in use as
biorecognition elements (bioreceptors) in biosensors since the early 1970s. They are an …

Living anisotropic structural color hydrogels for cardiotoxicity screening

D Xu, Y Wang, L Sun, Z Luo, Y Luo, Y Wang, Y Zhao - ACS nano, 2023 - ACS Publications
Environmental toxins can result in serious and fatal damage in the human heart, while the
development of a viable stratagem for assessing the effects of environmental toxins on …

Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

K Andrysiak, J Stępniewski, J Dulak - Pflügers Archiv-European Journal of …, 2021 - Springer
Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

Microengineered platforms for characterizing the contractile function of in vitro cardiac models

W Dou, M Malhi, Q Zhao, L Wang, Z Huang… - Microsystems & …, 2022 - nature.com
Emerging heart-on-a-chip platforms are promising approaches to establish cardiac
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations

C Le Dour, M Chatzifrangkeskou, C Macquart… - Nature …, 2022 - nature.com
Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation

M Raudenska, M Kratochvilova, T Vicar, J Gumulec… - Scientific reports, 2019 - nature.com
We focused on the biomechanical and morphological characteristics of prostate cancer cells
and their changes resulting from the effect of docetaxel, cisplatin, and long-term zinc …

Recent advances in AFM-based biological characterization and applications at multiple levels

W Liang, H Shi, X Yang, J Wang, W Yang, H Zhang… - Soft Matter, 2020 - pubs.rsc.org
Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few
decades due to its ability to measure biological samples in natural environments at a high …

Non-invasive electromechanical cell-based biosensors for improved investigation of 3D cardiac models

G Caluori, J Pribyl, M Pesl, S Jelinkova… - Biosensors and …, 2019 - Elsevier
Cardiomyocytes (CM) placed on microelectrode array (MEA) were simultaneously probed
with cantilever from atomic force microscope (AFM) system. This electric/nanomechanical …

Human induced pluripotent stem-cell-derived cardiomyocytes as models for genetic cardiomyopathies

A Brodehl, H Ebbinghaus, MA Deutsch… - International journal of …, 2019 - mdpi.com
In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …