BACKGROUND: Liver biopsy is the reference standard for diagnosing the extent of fibrosis
in chronic liver disease; however, it is invasive, with the potential for serious complications …

Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in
advancing disease. Measuring health related quality of life (HRQOL) in liver disease …

Osteoarthritis (OA) is a highly prevalent and disabling condition that affects over 7% of
people globally (528 million people). Prevalence levels are even higher in countries with …

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease. There is
uncertainty around the economic burden of NAFLD. We constructed a steady‐state …

Background & Aims Both hepatic resection and radiofrequency ablation (RFA) are
considered curative treatments for hepatocellular carcinoma (HCC), but their economic …

Background: New regimens for hepatitis C virus (HCV) have shorter treatment durations and
increased rates of sustained virologic response compared with existing therapies but are …

Background & Aims Chronic liver (CLD) is a major public health concern. We assessed its
effects on quality of life and work productivity, as well as its economic burden in the United …

Background: Obesity and knee osteoarthritis are among the most frequent chronic
conditions affecting Americans aged 50 to 84 years. Objective: To estimate quality-adjusted …

Background: Chronic hepatitis C virus is difficult to treat and affects approximately 3 million
Americans. Protease inhibitors increase the effectiveness of standard therapy, but they are …

Background & Aims Most persons infected with hepatitis C virus (HCV) in the United States
were born from 1945 through 1965; testing is recommended for this cohort. However, HCV …