Vaccine production to protect animals against pathogenic clostridia

NE Zaragoza, CA Orellana, GA Moonen, G Moutafis… - Toxins, 2019 - mdpi.com
Clostridium is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive
bacteria that can be found in different environments all around the world. The genus …

Clostridium septicum: A review in the light of alpha-toxin and development of vaccines

MLF Alves, MRA Ferreira, RA Donassolo… - Vaccine, 2021 - Elsevier
Clostridium septicum (CS) is a pathogen that can cause the death of animals in livestock
worldwide through its main virulence factor, alpha-toxin (ATX). The aspects involved in …

Immunity, immunomodulation, and antibiotic alternatives to maximize the genetic potential of poultry for growth and disease response

WH Kim, HS Lillehoj - Animal Feed Science and Technology, 2019 - Elsevier
Multiple challenges confront the increasing demand for wholesome poultry food products,
including governmental restrictions on the use of antibiotic growth promoters (AGPs) …

Dietary supplementation of young broiler chickens with Capsicum and turmeric oleoresins increases resistance to necrotic enteritis

SH Lee, HS Lillehoj, SI Jang, EP Lillehoj… - British Journal of …, 2013 - cambridge.org
The Clostridium-related poultry disease, necrotic enteritis (NE), causes substantial economic
losses on a global scale. In the present study, a mixture of two plant-derived phytonutrients …

Immune modulation by Bacillus subtilis-based direct-fed microbials in commercial broiler chickens

KW Lee, DK Kim, HS Lillehoj, SI Jang… - Animal feed science and …, 2015 - Elsevier
Abstract Direct-fed microbials (DFMs), also known as probiotics, have been successfully
used to improve the balance of gut microbiota. Spores of Bacillus subtilis, have been used …

Phylogenetic and genomic analysis reveals high genomic openness and genetic diversity of Clostridium perfringens

Y Feng, X Fan, L Zhu, X Yang, Y Liu… - Microbial …, 2020 - microbiologyresearch.org
Clostridium perfringens is associated with a variety of diseases in both humans and animals.
Recent advances in genomic sequencing make it timely to re-visit this important pathogen …

Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental …

SI Jang, HS Lillehoj, SH Lee, KW Lee, EP Lillehoj… - Vaccine, 2012 - Elsevier
This study was performed to compare four Clostridium perfringens recombinant proteins as
vaccine candidates using the Montanide™ ISA 71 VG adjuvant in an experimental model of …

Effect of Bacillus-based direct-fed microbials on Eimeria maxima infection in broiler chickens

KW Lee, HS Lillehoj, SI Jang, G Li, SH Lee… - … and Infectious Diseases, 2010 - Elsevier
The effect of dietary Bacillus-based direct-fed microbials (DFMs; eight single strains
designated as Bs2084, LSSAO1, 3AP4, Bs18, 15AP4, 22CP1, Bs27, and Bs278, and one …

Differential modulation of cytokine, chemokine and Toll like receptor expression in chickens infected with classical and variant infectious bursal disease virus

A Rauf, M Khatri, MV Murgia, K Jung, YM Saif - Veterinary research, 2011 - Springer
Infectious bursal disease (IBD) is an important immunosuppressive disease of chickens. The
causative agent, infectious bursal disease virus (IBDV), consists of two serotypes, 1 and 2 …

Gangrenous dermatitis in chickens and turkeys

CD Gornatti-Churria, M Crispo… - Journal of …, 2018 - journals.sagepub.com
Gangrenous dermatitis (GD) is a disease of chickens and turkeys that causes severe
economic losses in the poultry industry worldwide. Clostridium septicum, Clostridium …