Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …

Helminths have evolved to become experts at subverting immune surveillance. Through
potent and persistent immune tempering, helminths can remain undetected in human …

Th17 cells are involved in the pathogenesis of many autoimmune diseases, but it is not clear
whether they play a pathogenic role in type 1 diabetes. Here we investigated whether …

Insulin-dependent diabetes mellitus (IDDM) is a disease that results from autoimmune
destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. The …

Type 1 diabetes is considered to be an autoimmune disease in which T lymphocytes
infiltrate the islets of pancreas and destroy the insulin producing beta cell population …

The spontaneous development of insulin dependent diabetes mellitus in non‐obese
diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell …

Cannabidinoids are components of the Cannabis sativa (marijuana) plant that have been
shown capable of suppressing inflammation and various aspects of cell-mediated immunity …

Summary Type 1 diabetes (T1D) animal models such as the nonobese diabetic (NOD)
mouse have improved our understanding of disease pathophysiology, but many candidate …

We have previously shown that nonobese diabetic (NOD) mice are selectively deficient in
α/β-T cell receptor (TCR)+ CD4− CD8− NKT cells, a defect that may contribute to their …

Insulin-dependent diabetes mellitus results from T cell-mediated destruction of insulin-
producing, pancreatic islet β cells. How this destruction takes place has remained elusive …