There have been many techniques developed in recent years to in silico model a variety of
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …

Diverse forms of resistance to anticancer drugs can lead to the failure of chemotherapy.
Drug resistance is one of the most intractable issues for successfully treating cancer in …

Background Trastuzumab is a first‐line targeted therapy for human epidermal growth factor
receptor‐2 (HER2)‐positive gastric cancer. However, the inevitable occurrence of acquired …

Drug resistance significantly limits the long-term effectiveness of targeted therapeutics for
cancer patients. Recent experimental studies have demonstrated that cancer cell …

Tumors are complex multicellular heterogeneous systems comprised of components that
interact with and modify one another. Tumor development depends on multiple factors …

The biological process and molecular functions involved in the cancer progression remain
difficult to understand for biologists and clinical doctors. Recent developments in high …

Simple Summary The recruitment of new vasculature via angiogenesis is a critical
component of tumor development, which fundamentally influences tumor growth and …

Tumor associated angiogenesis is the development of new blood vessels in response to
proteins secreted by tumor cells. These new blood vessels allow tumors to continue to grow …

Osteogenetic microenvironment is a complex constitution in which extracellular matrix
(ECM) molecules, stem cells and growth factors each interact to direct the coordinate …

Hybrid multiscale agent-based models (ABMs) are unique in their ability to simulate
individual cell interactions and microenvironmental dynamics. Unfortunately, the high …