Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Objective: To identify an appropriate diagnostic tool for the early diagnosis of acute traumatic
coagulopathy and validate this modality through prediction of transfusion requirements in …

Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental
to effective clot formation. There is increasing awareness of the important role of fibrinogen …

Fibrinogen plays several key roles in the maintenance of hemostasis. Its cleavage by
thrombin and subsequent polymerization to form fibrin strands provides the structural …

Introduction Viscoelastic assays have been promoted as an improvement over traditional
coagulation tests in the management of trauma patients. Rotational thromboelastometry …

Fibrinogen is a critical protein for hemostasis and clot formation. However, transfusion
guidelines have variable recommendations for maintaining fibrinogen levels in bleeding …

Introduction The purpose of this study was to re-evaluate the findings of a smaller cohort
study on the functional definition and characteristics of acute traumatic coagulopathy (ATC) …

Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when
bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury …