The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential
structural role, especially in cell membranes where they also possess signaling properties …

Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage
in acute myocardial infarction, and its treatment remains a clinical challenge. Ginsenoside …

The road to low-dose aspirin therapy for the prevention of preeclampsia began in the 1980s
with the discovery that there was increased thromboxane and decreased prostacyclin …

The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains
unknown. Here, we found that S1P or FTY720 (an analog of S1P) promoted microglial …

Abstract Sphingosine-1-phosphate (S1P) is a sphingolipid mediator that exerts a variety of
biological functions, including immune, cardiovascular, and neurological regulation as well …

Ageing is a physiological/pathological process accompanied by the progressive damage of
cell function, triggering various ageing-related disorders. Phosphatidylinositol 3-kinase …

Nowadays, cardiovascular diseases (CVDs) are a global threat to public health, accounting
for almost one‐third of all deaths worldwide. One of the key mechanistic pathways …

Cadmium (Cd) is a toxic metal pollutant that still exists in the environment. The microRNA
(miRNA) is a type of noncoding RNA that plays an important role in gene posttranscriptional …

Parkinson's disease (PD) is the second-most common neurodegenerative disease in the
world, affecting up to 10 million people. This disease mainly happens due to the loss of …