“Top-down” proteomics analyzes intact proteins and identifies proteoforms by their intact
mass as well as the observed fragmentation pattern in tandem mass spectrometry (MS/MS) …

Neuropeptides are a class of endogenous peptides that have key regulatory roles in
biochemical, physiological, and behavioral processes. Mass spectrometry analyses of …

Diverse proteomics-based strategies have been applied to saliva to quantitatively identify
diagnostic and prognostic targets for oral cancer. Considering that these targets may be …

Charging of analytes is a prerequisite for performing mass spectrometry analysis. In
proteomics, electrospray ionization is the dominant technique for this process. Although the …

Current proteomics approaches rely almost exclusively on using the positive ionization
mode, resulting in inefficient ionization of many acidic peptides. This study investigates …

Detection of peptides from mass spectrometric data lies at the core of computational
proteomics. In our research, we focus on detecting variant peptides—a large class of …