Understanding and treating niemann–pick type c disease: Models matter

V Pallottini, FW Pfrieger - International Journal of Molecular Sciences, 2020 - mdpi.com
Biomedical research aims to understand the molecular mechanisms causing human
diseases and to develop curative therapies. So far, these goals have been achieved for a …

Characterization of Oxygen Nanobubbles and In Vitro Evaluation of Retinal Cells in Hypoxia

V Messerschmidt, W Ren, M Tsipursky… - … Vision Science & …, 2023 - tvst.arvojournals.org
Purpose: Vein or artery occlusion causes a hypoxic environment by preventing oxygen
delivery and diffusion to tissues. Diseases such as retinal vein occlusion, central retinal …

Relation of retinal oxygen measures to electrophysiology and survival indicators after permanent, incomplete ischemia in rats

N Matei, S Leahy, S Auvazian, B Thomas… - Translational stroke …, 2020 - Springer
Studies in experimental ischemia models by permanent bilateral common carotid artery
occlusion (BCCAO) have reported reduced retinal electrophysiological function, coupled …

Prognosis and factors related to anti-VEGF therapy in patients with retinal vein occlusion and concomitant carotid artery disease

T Yang, Y Lu, F Zeng, R Yu, C Zou, R Hu, G Jin… - Scientific Reports, 2024 - nature.com
To evaluate the prognosis and influencing factors of retinal vein occlusion (RVO) in patients
with concomitant carotid artery disease receiving anti-vascular endothelial growth factor …

[HTML][HTML] Optimization of an Ischemic Retinopathy Mouse Model and the Consequences of Hypoxia in a Time-Dependent Manner

I Bosnyak, N Farkas, D Molitor, B Meresz… - International Journal of …, 2024 - mdpi.com
The retina is one of the highest metabolically active tissues with a high oxygen consumption,
so insufficient blood supply leads to visual impairment. The incidence of related conditions is …

Retinal oxygen delivery, metabolism, and extraction fraction during long-term bilateral common carotid artery occlusion in rats

S Leahy, S Farzad, NP Blair, M Shahidi - Scientific Reports, 2020 - nature.com
Retinal functional, biochemical, and anatomical changes have been previously reported in
long-term experimental permanent bilateral common carotid artery occlusion (BCCAO). The …

Retinal oxygen delivery and metabolism response to hyperoxia during bilateral common carotid artery occlusion in rats

S Leahy, N Matei, NP Blair… - … Ophthalmology & Visual …, 2022 - iovs.arvojournals.org
Purpose: The purpose of the current study was to test the hypothesis that responses of total
retinal blood flow (TRBF), inner retinal oxygen delivery (DO 2), metabolism (MO 2), and …

Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion

B Li, J Leng, I Şencan-Eğilmez, H Takase… - …, 2023 - spiedigitallibrary.org
Significance It has been hypothesized that abnormal microcirculation in the retina might
predict the risk of ischemic damages in the brain. Direct comparison between the retinal and …

The accumulated oxygen deficit as an indicator of the ischemic retinal insult

NP Blair, N Matei, S Leahy, M Rahimi… - Experimental eye …, 2023 - Elsevier
We here attempt to improve quantification of the ischemic retinal insult, that is, what is
imposed on the retinal tissue by ischemia, especially in experimental models of ischemia …

视网膜静脉阻塞患者抗血管内皮生长因子治疗后视力差的影响因素.

杨婷婷, 刘家艳, 曾凤, 卢亚梅 - Guangdong Medical Journal, 2024 - search.ebscohost.com
目的评估视网膜静脉阻塞(RVO) 患者接受抗血管内皮生长因子(VEGF) 治疗后视力差的影响因素
. 方法以2018 年6 月至2023 年6 月期间在广州医科大学附属清远医院诊断为RVO …