Fast-forward on P-type ATPases: recent advances on structure and function
C Stock, T Heger, S Basse Hansen… - Biochemical Society …, 2023 - portlandpress.com
P-type ATPase are present in nearly all organisms. They maintain electrochemical gradients
for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial …
for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial …
[HTML][HTML] Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states
Y Guo, Y Zhang, R Yan, B Huang, F Ye, L Wu… - Nature …, 2022 - nature.com
Abstract Sodium-Potassium Pump (Na+/K+-ATPase, NKA) is an ion pump that generates an
electrochemical gradient of sodium and potassium ions across the plasma membrane by …
electrochemical gradient of sodium and potassium ions across the plasma membrane by …
A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities
P Artigas, DJ Meyer, VC Young… - Proceedings of the …, 2023 - National Acad Sciences
Brine shrimp (Artemia) are the only animals to thrive at sodium concentrations above 4 M.
Salt excretion is powered by the Na+, K+-ATPase (NKA), a heterodimeric (αβ) pump that …
Salt excretion is powered by the Na+, K+-ATPase (NKA), a heterodimeric (αβ) pump that …
[HTML][HTML] Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms
VC Young, H Nakanishi, DJ Meyer, T Nishizawa… - Nature …, 2022 - nature.com
Ion-transport mechanisms evolve by changing ion-selectivity, such as switching from Na+ to
H+ selectivity in secondary-active transporters or P-type-ATPases. Here we study primary …
H+ selectivity in secondary-active transporters or P-type-ATPases. Here we study primary …
Structural basis for binding of potassium-competitive acid blockers to the gastric proton pump
S Tanaka, M Morita, T Yamagishi… - Journal of Medicinal …, 2022 - ACS Publications
As specific inhibitors of the gastric proton pump, responsible for gastric acidification, K+-
competitive acid blockers (P-CABs) have recently been utilized in the clinical treatment of …
competitive acid blockers (P-CABs) have recently been utilized in the clinical treatment of …
[HTML][HTML] An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding
K Abe, T Nishizawa, P Artigas - … et Biophysica Acta (BBA)-Molecular Cell …, 2023 - Elsevier
Abstract The Na+, K+-ATPase (NKA) and non-gastric H+, K+-ATPase (ngHKA) share~ 65%
sequence identity, and nearly identical catalytic cycles. These pumps alternate between …
sequence identity, and nearly identical catalytic cycles. These pumps alternate between …
[HTML][HTML] Deep learning driven de novo drug design based on gastric proton pump structures
K Abe, M Ozako, M Inukai, Y Matsuyuki… - Communications …, 2023 - nature.com
Existing drugs often suffer in their effectiveness due to detrimental side effects, low binding
affinity or pharmacokinetic problems. This may be overcome by the development of distinct …
affinity or pharmacokinetic problems. This may be overcome by the development of distinct …