Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Breast cancer stem cells (BCSCs) play a critical role in cancer recurrence and metastasis.
Chemotherapy induces BCSC specification through increased expression of pluripotency …

Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …

Aberrant epigenetic modifications are emerging as potent drivers of tumor initiation and
progression. The deregulation of H3K27me3 marks has shown to play an important role in …

Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen
species (ROS), and high levels of GSH promote cancer cell survival and resistance to …

Recently, studies have been suggested that H3K27me3 is implicated with maintenance of
cancer stem cells (CSCs), however, the roles of H3K27me3 in Breast cancer stem cells …

Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of
aging per se, has been clinically exploited for decades in the absence of a complete …

Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering
only palliation. Inter‐and intrapatient heterogeneity is a hallmark of GBM, with epigenetically …

Lung cancer is one of the most common malignancies. In spite of the progress made in past
decades, further studies to improve current therapy for lung cancer are required …