Aging is associated with dysregulation of glucose and lipid metabolism. Various factors that
contribute to the dysregulation include both modifiable (eg obesity, insulin resistance) and …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver
disorders and has a strong heritable component. The aim of this study was to identify new …

Fibronectin type III domain-containing 5 (FNDC5) protein induces browning of subcutaneous
fat and mediates the beneficial effects of exercise on metabolism. However, whether FNDC5 …

Abstract Fibroblast growth factor 21 (FGF21) plays an important role in regulating glucose
and lipid metabolism, but its role in cancer is less well-studied. We aimed to investigate the …

Nonalcoholic fatty liver disease (NAFLD) is characterized by excess liver fat infiltration
(steatosis in 5% of hepatocytes) in the absence of significant alcohol consumption or other …

Abnormal accumulation of lipids in liver leads to uncontrolled endoplasmic reticulum (ER)
stress and autophagy. Luteolin is known to have antioxidant, anti-inflammatory, and anti …

The mechanisms underlying glucocorticoid (GC)-increased adiposity are poorly understood.
Brown adipose tissue (BAT) acquires white adipose tissue (WAT) cell features defined as …

Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di-and tri-methylates lysine-
27 of histone H3, largely functions as a transcriptional repressor, and plays a critical role in …

Objective Non-alcoholic fatty liver disease is characterized by high hepatic triacylglycerol
contents, which is associated with endoplasmic reticulum (ER) stress and insulin resistance …

Irbesartan (Irb), a unique subset of angiotensin II receptor blockers (ARBs) with PPAR-γ
activation function, has been reported to play a role in renal dysfunction, glucose …