The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …

Decoding the interactions of transition metal complexes with proteins is still an open
challenge in many fields, like biology and medicinal chemistry, or in the design of de novo …

Non-heme iron halogenases and hydroxylases activate inert C–H bonds to selectively
catalyze the functionalization of diverse biological products under physiological conditions …

Sulfoquinovose (SQ) is one of the most abundant organosulfur compounds in the biosphere,
and its biosynthesis and degradation can represent an important contribution to the sulfur …

Endoperoxide-containing natural products are a group of compounds with structurally
unique cyclized peroxide moieties. Although numerous endoperoxide-containing …

Mechanisms of enzymatic epoxidation via oxygen atom transfer (OAT) to an olefin moiety is
mainly derived from the studies on thiolate-heme containing epoxidases, such as …

Hyoscyamine 6β-hydroxylase (H6H) is an iron (II)-and 2-oxoglutarate-dependent (Fe/2OG)
oxygenase that produces the prolifically administered antinausea drug, scopolamine. After …

Chemo-and regio-selective catalysis of the C (sp3)-H halogenation reaction is a formidable
goal in chemical synthesis. 2-Oxoglutarate (2OG)-dependent non-heme iron halogenases …

The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical
reactions using a common high-spin FeIV═ O intermediate that, in most reactions, abstract a …

We study active-site models of nonheme iron hydroxylases and their vanadium-based
mimics using density functional theory to determine if vanadyl is a faithful structural mimic …