Molecular mechanism of HIV-1 entry
B Chen - Trends in microbiology, 2019 - cell.com
HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
HIV genome-wide protein associations: a review of 30 years of research
G Li, E De Clercq - Microbiology and Molecular Biology Reviews, 2016 - Am Soc Microbiol
The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …
cooperative associations among HIV proteins and between HIV and host proteins, to invade …
Structural basis of coreceptor recognition by HIV-1 envelope spike
MM Shaik, H Peng, J Lu, S Rits-Volloch, C Xu, M Liao… - Nature, 2019 - nature.com
Abstract HIV-1 envelope glycoprotein (Env), which consists of trimeric (gp160) 3 cleaved to
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
P Padmanabhan, R Desikan… - PLoS computational …, 2020 - journals.plos.org
The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein,
S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin …
S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin …
Modeling viral spread
F Graw, AS Perelson - Annual review of virology, 2016 - annualreviews.org
The way in which a viral infection spreads within a host is a complex process that is not well
understood. Different viruses, such as human immunodeficiency virus type 1 and hepatitis C …
understood. Different viruses, such as human immunodeficiency virus type 1 and hepatitis C …
Super-resolution fluorescence imaging reveals that serine incorporator protein 5 inhibits human immunodeficiency virus fusion by disrupting envelope glycoprotein …
Serine incorporator protein 5 (SERINC5) is the host antiretroviral factor that reduces HIV-1
infectivity by incorporating into virions and inhibiting the envelope glycoprotein (Env) …
infectivity by incorporating into virions and inhibiting the envelope glycoprotein (Env) …
Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane
The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their
infection by an incompletely understood mechanism. We have previously reported that …
infection by an incompletely understood mechanism. We have previously reported that …
[HTML][HTML] Modelling how increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant may affect the efficacy and …
P Padmanabhan, NM Dixit - Journal of Theoretical Biology, 2023 - Elsevier
Abstract The SARS-CoV-2 Omicron variant harbours many mutations in its spike protein
compared to the original SARS-CoV-2 strain, which may alter its ability to enter cells, cell …
compared to the original SARS-CoV-2 strain, which may alter its ability to enter cells, cell …
Functional organization of the HIV lipid envelope
N Huarte, P Carravilla, A Cruz, M Lorizate… - Scientific reports, 2016 - nature.com
The chemical composition of the human immunodeficiency virus type 1 (HIV-1) membrane is
critical for fusion and entry into target cells, suggesting that preservation of a functional lipid …
critical for fusion and entry into target cells, suggesting that preservation of a functional lipid …