Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

ATP-binding cassette (ABC) transporters shuttle a wide variety of molecules across cell
membranes by alternating between inward-and outward-facing conformations, harnessing …

An ATP-binding cassette transporter located in the inner mitochondrial membrane is
involved in iron-sulfur cluster and molybdenum cofactor assembly in the cytosol, but the …

Multidrug efflux pumps present a challenge to the treatment of bacterial infections, making it
vitally important to understand their mechanism of action. Here, we investigate the nature of …

We describe a general mass spectrometry approach to determine subunit stoichiometry and
lipid binding in intact membrane protein complexes. By exploring conditions for preserving …

Multidrug ABC transporters such as the human multidrug resistance P-glycoprotein (ABCB1)
play an important role in the extrusion of drugs from the cell and their overexpression can be …

The world's oceans are a global reservoir of persistent organic pollutants to which humans
and other animals are exposed. Although it is well known that these pollutants are …

Sav1866 is an ATP-binding cassette (ABC) protein from the pathogen Staphylococcus
aureus and is a homologue of bacterial and human multidrug ABC transporters. Recently …

ATP-binding cassette transporters mediate the transbilayer movement of a vast number of
substrates in or out of cells in organisms ranging from bacteria to humans. Current …