The efficiency of treatment of human infections with the unicellular eukaryotic pathogens
such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates …

Propolis is known for its biological properties and its preparations have been continuously
investigated in an attempt to solve the problem of their standardization, an issue that limits …

The discovery of the involvement of nitric oxide (NO) in several physiological and
pathophysiological processes launched a spectacular increase in studies in areas such as …

Background The two available drugs for treatment of T. cruzi infection, nifurtimox and
benznidazole (BZ), have potential toxic side effects and variable efficacy, contributing to their …

Chronic Chagasic cardiomyopathy develops years after infection in 20–40% of patients, but
disease progression is poorly understood. Here, we assessed Trypanosoma cruzi parasite …

As an intracellular parasite, Trypanosoma cruzi is exposed to reactive oxygen species. The
study of the proteins involved in the hydroperoxide detoxification cascade, tryparedoxin …

We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and
twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan …

Background and purpose: Many compounds liberating NO (NO donors) have been used as
therapeutic agents. Here we test two ruthenium nitrosyls, which release NO when activated …

Chagas disease and sleeping sickness are neglected tropical diseases closely related to
poverty, for which the development of plant-derived treatments has not been a promising …

The trypanocidal effect of six lignan lactones,(−)-cubebin (1),(−)-O-methyl cubebin (2),(−)-O-
benzyl cubebin (3),(−)-6, 6′-dinitrohinokinin (4),(−)-hinokinin (5) and dimethoxymorelensin …