[HTML][HTML] Emergence of microfluidics for next generation biomedical devices
The attention in lab-on-a-chip devices with their potent application in medical engineering
has prolonged swiftly over the last ten years. Travelling through the technology …
has prolonged swiftly over the last ten years. Travelling through the technology …
3D bioprinted organ‐on‐chips
S Rahmani Dabbagh, M Rezapour Sarabi… - …, 2023 - Wiley Online Library
Abstract Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more
realistically compared to many animal models and conventional two‐dimensional cell …
realistically compared to many animal models and conventional two‐dimensional cell …
Bioprinting of 3D convoluted renal proximal tubules on perfusable chips
Three-dimensional models of kidney tissue that recapitulate human responses are needed
for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we …
for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we …
Renal reabsorption in 3D vascularized proximal tubule models
Three-dimensional renal tissues that emulate the cellular composition, geometry, and
function of native kidney tissue would enable fundamental studies of filtration and …
function of native kidney tissue would enable fundamental studies of filtration and …
[HTML][HTML] Development of a microphysiological model of human kidney proximal tubule function
EJ Weber, A Chapron, BD Chapron, JL Voellinger… - Kidney international, 2016 - Elsevier
The kidney proximal tubule is the primary site in the nephron for excretion of waste products
through a combination of active uptake and secretory processes and is also a primary target …
through a combination of active uptake and secretory processes and is also a primary target …
Patient-iPSC-derived kidney organoids show functional validation of a ciliopathic renal phenotype and reveal underlying pathogenetic mechanisms
Despite the increasing diagnostic rate of genomic sequencing, the genetic basis of more
than 50% of heritable kidney disease remains unresolved. Kidney organoids differentiated …
than 50% of heritable kidney disease remains unresolved. Kidney organoids differentiated …
Three-dimensional cell-printing of advanced renal tubular tissue analogue
Despite significant progress in the development of renal tissue, recapitulation of perfusable
complex renal tubular tissue with clinically relevant cellular heterogeneity is still remaining a …
complex renal tubular tissue with clinically relevant cellular heterogeneity is still remaining a …
Kidney-based in vitro models for drug-induced toxicity testing
The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …
Advances in predictive in vitro models of drug-induced nephrotoxicity
JYC Soo, J Jansen, R Masereeuw… - Nature Reviews …, 2018 - nature.com
In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …
Although the functional proteins that are expressed by nephron tubules and mediate drug …
Microfluidic bioprinting for organ-on-a-chip models
F Yu, D Choudhury - Drug discovery today, 2019 - Elsevier
Highlights•Bioprinting can be used to fabricate organ-on-a-chip models owing to its ability to
print multiple materials and cell types simultaneously with good spatial resolution and …
print multiple materials and cell types simultaneously with good spatial resolution and …