Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

The cerebral cortex underwent rapid expansion and increased complexity during recent
hominid evolution. Gene duplications constitute a major evolutionary force, but their impact …

The Notch protein is one of the most mechanistically direct transmembrane receptors—the
intracellular domain contains a transcriptional regulator that is released from the membrane …

A revolution in cellular measurement technology is under way: For the first time, we have the
ability to monitor global gene regulation in thousands of individual cells in a single …

Cell communication within tissues is mediated by multiple paracrine signals including
growth factors, which control cell survival and proliferation. Cells and the growth factors they …

The Notch signaling pathway comprises multiple ligands that are used in distinct biological
contexts. In principle, different ligands could activate distinct target programs in signal …

Monitoring of cell-cell communication in multicellular organisms is fundamental to
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …

Endothelial cells (ECs) provide angiocrine factors orchestrating tumor progression. Here, we
show that activated Notch1 receptors (N1ICD) are frequently observed in ECs of human …