Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Introduction Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the development of major depressive disorder (MDD) in adulthood. Less work …

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …

Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Metformin as a first-line drug for type 2 diabetes mellitus (T2DM) treatment is widely studied.
Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence …

Depression and anxiety are the most common mental illnesses affecting children and
adolescents, significantly harming their well-being. Research has shown that regular …

Major depressive disorder (MDD) is a devastating disease affecting over 300 million people
worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in …

A comprehensive overview of the interplay between glucocorticoids (GCs) and adult
hippocampal neurogenesis (AHN) is presented, particularly, in the context of a diseased …

A paradigm shift in neuroscience was the discovery that new neurons are constantly
produced in the adult mammalian brain of several species, including Homo sapiens. These …

Neurogenesis, the process in which new neurons are generated, occurs throughout life in
the mammalian hippocampus. Decreased adult hippocampal neurogenesis (AHN) is a …