The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

Radiation therapy is one of the most common treatment strategies for thorax malignancies.
One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is …

The pulmonary alveolus, terminal gas-exchange unit of the lung, is composed of alveolar
epithelial and endothelial cells separated by a thin basement membrane and interstitial …

Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

Recognition of external mechanical signals is vital for mammalian cells. Cyclic stretch, eg
around blood vessels, is one such signal that induces cell reorientation from parallel to …

The respiratory epithelium is a physical and functional barrier actively involved in the
clearance of environmental agents. The alveolar compartment is lined with membranous …

Alveolar macrophages are the first line of defense against intruding pathogens and play a
critical role in cancer immunology. The Toll-like receptor (TLR) family mediates an important …

Protein supplementation therapy using in vitro-transcribed (IVT) mRNA for genetic diseases
contains huge potential as a new class of therapy. From the early ages of synthetic mRNA …

The human respiratory tract of individuals with normal lung function maintains a fine-tuned
balance, being asymptomatically colonised by the normal microbiota in the upper airways …

Once thought of in terms of bioenergetics, mitochondria are now widely accepted as both the
orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field …