The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

LPS is a potent trigger of macrophage-mediated inflammation. However, prolonged
exposure to LPS induces a state of tolerance that reprograms the inflammatory response …

Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

MicroRNAs are fine tuners of diverse biological responses and are expressed in various cell
types of the liver. Here we hypothesized that circulating microRNAs (miRNAs) may serve as …

Like other body districts, lungs present a complex bacteria community. An emerging function
of lung microbiota is to promote and maintain a state of immune tolerance, to prevent …

Sepsis is characterized as an uncontrolled host response to infection, and it represents a
serious health challenge, causing excess mortality and morbidity worldwide. The discovery …

The efficacy of macrophage-mediated inflammatory response relies on the coordinated
expression of key factors, which expression is finely regulated at both transcriptional and …

The role of myelomonocytic cells like monocytes and macrophages as first line of host
defense is well established. Recent understanding of these cells using systems biology …