Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …

During cell migration, the movement of the nucleus must be coordinated with the
cytoskeletal dynamics at the leading edge and trailing end, and, as a result, undergoes …

Background: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment
to the plasmatic membrane. FLNC mutations have been associated with myofibrillar …

Emery‐Dreifuss muscular dystrophy (EDMD) is a rare muscular dystrophy, but is particularly
important to diagnose due to frequent life‐threatening cardiac complications. EDMD …

In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell
surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to …

The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …

Muscular dystrophy (MD) connotes a heterogeneous group of inherited disorders
characterized by progressive wasting and weakness of the skeletal muscles. In several …

Background Atrial fibrillation (AF) is a common arrhythmia seen in clinical practice.
Occasionally, no common risk factors are present in patients with this arrhythmia. This …

Genetic testing is highly useful in the care of patients and families, as it guides diagnosis,
influences care and aids in prognosis. However, the large amount of benign human genetic …

Shear stress, especially low shear stress (LowSS), plays an important role in vascular
remodeling during atherosclerosis. Endothelial cells (ECs), which are directly exposed to …