Challenges in the clinical implementation of precision medicine companion diagnostics

P Keeling, J Clark, S Finucane - Expert review of molecular …, 2020 - Taylor & Francis
Introduction The pace of biomarker discovery has increased exponentially over the last few
years, ushering in an era of precision medicine (PM) with a growing arsenal of treatments …

Economic evaluation of pharmacogenomics: a value-based approach to pragmatic decision making in the face of complexity

SR Snyder, C Mitropoulou, GP Patrinos… - Public Health …, 2014 - karger.com
Evidence of the value of pharmacogenomic testing is needed to inform policymakers and
clinicians for decision making related to adoption and coverage, and to facilitate …

Delivering the precision oncology paradigm: reduced R&D costs and greater return on investment through a companion diagnostic informed precision oncology …

RH Henderson, D French, E Stewart, D Smart… - … of Pharmaceutical Policy …, 2023 - Springer
Background Precision oncology medicines represent a paradigm shift compared to non-
precision oncology medicines in cancer therapy, in some situations delivering more clinical …

International consortium for personalized medicine: an international survey about the future of personalized medicine

J Venne, U Busshoff, S Poschadel… - Personalized …, 2020 - Taylor & Francis
Aim: The ICPerMed, international initiative promoting personalized medicine, has realized a
survey among a group of experts, to define a common vision for the deployment of …

P2P cloud manufacturing based on a customized business model: An exploratory study

D Huang, M Li, J Fu, X Ding, W Luo, X Zhu - Sensors, 2023 - mdpi.com
To overcome the problems of long production cycle and high cost in the product
manufacturing process, a P2P (platform to platform) cloud manufacturing method based on a …

Development and pilot-test of blockchain-based MyHealthData platform

YS Bae, Y Park, T Kim, T Ko, MS Kim, E Lee, HC Kim… - Applied Sciences, 2021 - mdpi.com
The concept of MyData emerged as a paradigm shift in personal data management and the
process of seeking to transform the current organization-centered system. MyData enables …

[HTML][HTML] Towards a systems approach for chronic diseases, based on health state modeling

M Rebhan - F1000Research, 2017 - ncbi.nlm.nih.gov
Rising pressure from chronic diseases means that we need to learn how to deal with
challenges at a different level, including the use of systems approaches that better connect …

Multiomics medicine in oncology: assessing effectiveness, cost–effectiveness and future research priorities for the molecularly unique individual

B Doble, A Harris, DM Thomas, S Fox… - …, 2013 - Taylor & Francis
The development of genomic technologies has ushered in the era of pharmacogenomics.
However, discoveries and clinical use of targeted therapies are still in their infancy. A focus …

Pharmacogenomic challenges in cardiovascular diseases: examples of drugs and considerations for future integration in clinical practice

J Chatelin, MG Stathopoulou… - Current …, 2017 - ingentaconnect.com
Introduction: Even if cardiovascular disease (CVD) drugs are supported by high level proofs,
the results of CVD treatment present great disparities: there are still patients dying with …

Economic viability of stratified medicine concepts: an investor perspective on drivers and conditions that favour using stratified medicine approaches in a cost …

HJ Fugel, M Nuijten, M Postma - New biotechnology, 2016 - Elsevier
Abstract Rationale Stratified Medicine (SM) is becoming a natural result of advances in
biomedical science and a promising path for the innovation-based biopharmaceutical …