Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential

BC Jiang, T Liu, YJ Gao - Pharmacology & therapeutics, 2020 - Elsevier
Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …

Interstitial cystitis/bladder pain syndrome: the evolving landscape, animal models and future perspectives

Y Akiyama, Y Luo, PM Hanno… - … Journal of Urology, 2020 - Wiley Online Library
Interstitial cystitis/bladder pain syndrome is a debilitating condition of unknown etiology
characterized by persistent pelvic pain with lower urinary tract symptoms and comprises a …

Broaden horizons: The advancement of interstitial cystitis/bladder pain syndrome

J Li, X Yi, J Ai - International Journal of Molecular Sciences, 2022 - mdpi.com
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease that induces
mental stress, lower urinary symptoms, and pelvic pain, therefore resulting in a decline in …

The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors

AV Golubeva, AV Zhdanov, G Mallel… - Physiological …, 2014 - Wiley Online Library
Painful bladder syndrome/Interstitial cystitis (PBS/IC) is a chronic disorder characterized
clinically by recurring episodes of pelvic pain and increased urination frequency …

TRPM3 is expressed in afferent bladder neurons and is upregulated during bladder inflammation

M Vanneste, M Mulier, AC Nogueira Freitas… - International Journal of …, 2021 - mdpi.com
The cation channel TRPM3 is activated by heat and the neurosteroid pregnenolone sulfate.
TRPM3 is expressed on sensory neurons innervating the skin, where together with TRPV1 …

Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model

F Bicer, CZ Altuntas, K Izgi, A Ozer… - American Journal …, 2015 - journals.physiology.org
The cause of chronic pelvic pain in interstitial cystitis/painful bladder syndrome (IC/PBS)
remains unclear; autoimmunity is a possible etiology. We have recently shown that injection …

[HTML][HTML] Comparison of 5 different rat models to establish a standard animal model for research into interstitial cystitis

PH Song, SY Chun, JW Chung, YY Kim… - International …, 2017 - ncbi.nlm.nih.gov
Purpose We evaluated 5 different rat models using different agents in order to establish a
standard animal model for interstitial cystitis (IC) in terms of the functional and pathologic …

Increased CXCR3 expression of infiltrating plasma cells in Hunner type interstitial cystitis

Y Akiyama, T Morikawa, D Maeda, Y Shintani, A Niimi… - Scientific reports, 2016 - nature.com
An up-regulated CXCR3 pathway and affluent plasma cell infiltration are characteristic
features of Hunner type interstitial cystitis (HIC). We further examined these two features …

Biomaterial-assisted drug delivery for interstitial cystitis/bladder pain syndrome treatment

Z Lin, H Hu, B Liu, Y Chen, Y Tao, X Zhou… - Journal of Materials …, 2021 - pubs.rsc.org
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and painful bladder condition
afflicting patients with increased urinary urgency and frequency as well as incontinence …

Animal models of interstitial cystitis/bladder pain syndrome

C Tay, L Grundy - Frontiers in Physiology, 2023 - frontiersin.org
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic disorder characterized by
pelvic and/or bladder pain, along with lower urinary tract symptoms that have a significant …