Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …

Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS of
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …

Abstract Interleukin (IL)-1β, a pro-inflammatory cytokine, was elevated and participates in
periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical …

Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological
diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha …

Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

Zika virus (ZIKV) infection is a public health emergency and host innate immunity is essential
for the control of virus infection. The NLRP3 inflammasome plays a key role in host innate …

The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the
defining pathological hallmark of Parkinson's disease (PD). Rare familial PD-associated …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …