Immune landscape and redox imbalance during neurological disorders in COVID-19
Abstract The outbreak of Coronavirus Disease 2019 (COVID-19) has prompted the scientific
community to explore potential treatments or vaccines against severe acute respiratory …
community to explore potential treatments or vaccines against severe acute respiratory …
[HTML][HTML] Harnessing genetic complexity to enhance translatability of Alzheimer's disease mouse models: a path toward precision medicine
SM Neuner, SE Heuer, MJ Huentelman… - Neuron, 2019 - cell.com
An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …
Interpretation of psychiatric genome-wide association studies with multispecies heterogeneous functional genomic data integration
T Reynolds, EC Johnson, SB Huggett… - …, 2021 - nature.com
Genome-wide association studies and other discovery genetics methods provide a means to
identify previously unknown biological mechanisms underlying behavioral disorders that …
identify previously unknown biological mechanisms underlying behavioral disorders that …
Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance
DP Hill, A Harper, J Malcolm, MS McAndrews… - BMC cancer, 2019 - Springer
Background Understanding mechanisms underlying specific chemotherapeutic responses
in subtypes of cancer may improve identification of treatment strategies most likely to benefit …
in subtypes of cancer may improve identification of treatment strategies most likely to benefit …
Mouse Phenome Database: towards a more FAIR-compliant and TRUST-worthy data repository and tool suite for phenotypes and genotypes
Abstract The Mouse Phenome Database (MPD; https://phenome. jax. org; RRID:
SCR_003212), supported by the US National Institutes of Health, is a Biomedical Data …
SCR_003212), supported by the US National Institutes of Health, is a Biomedical Data …
Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease
ME Dolan, DP Hill, G Mukherjee, MS McAndrews… - Scientific reports, 2020 - nature.com
The emergence of the SARS-CoV-2 virus and subsequent COVID-19 pandemic initiated
intense research into the mechanisms of action for this virus. It was quickly noted that COVID …
intense research into the mechanisms of action for this virus. It was quickly noted that COVID …
[HTML][HTML] CTD anatomy: analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies
AP Davis, TC Wiegers, J Wiegers, CJ Grondin… - Current research in …, 2021 - Elsevier
Abstract The Comparative Toxicogenomics Database (CTD) is a freely available public
resource that curates and interrelates chemical, gene/protein, phenotype, disease …
resource that curates and interrelates chemical, gene/protein, phenotype, disease …
Gene set summarization using large language models
Molecular biologists frequently interpret gene lists derived from high-throughput experiments
and computational analysis. This is typically done as a statistical enrichment analysis that …
and computational analysis. This is typically done as a statistical enrichment analysis that …
Prediction of the mechanisms by which quercetin enhances cisplatin action in cervical cancer: a network pharmacology study and experimental validation
H Ji, K Li, W Xu, R Li, S Xie, X Zhu - Frontiers in Oncology, 2022 - frontiersin.org
Yimucao has been used as an herbal medicine to treat gynecological diseases. Common
genes of Yimucao active compounds were investigated using network pharmacology. The …
genes of Yimucao active compounds were investigated using network pharmacology. The …
An emerging multi-omic understanding of the genetics of opioid addiction
Opioid misuse, addiction, and associated overdose deaths remain global public health
crises. Despite the tremendous need for pharmacological treatments, current options are …
crises. Despite the tremendous need for pharmacological treatments, current options are …