Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

The large-scale applications of Triclosan in industrial and household products have created
many health and environmental concerns. Despite the fears of its drug-resistance and other …

Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact
sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the …

Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by
mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although …

Ca2+ is the most ubiquitous second messenger in neurons whose spatial and temporal
elevations are tightly controlled to initiate and orchestrate diverse intracellular signaling …

The number and activity of Cav1. 2 channels in the cardiomyocyte sarcolemma tunes the
magnitude of Ca2+-induced Ca2+ release and myocardial contraction. β-Adrenergic …

Our ability to learn and remember depends on the active formation, remodeling, and
elimination of synapses. Thus, the development and growth of synapses as well as their …

About two thirds of the patients affected with lysosomal storage diseases (LSD) experience
neurological manifestations, such as developmental delay, seizures, or psychiatric …

Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in
cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular …

Since the 1970s, the emergence and expansion of novel methods for calcium ion (Ca2+)
detection have found diverse applications in vitro and in vivo across a series of model …