The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …

Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart
failure. Detailed deciphering gene expression perturbations and cell–cell interactions of …

Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …

Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful
infections and malignant transformation but also can instigate autoimmune reactions. Similar …

T cells differentiate into functionally distinct states upon antigen encounter. These states are
delineated by different cell surface markers for murine and human T cells, which hamper …

Chimeric antigen receptor (CAR) T cells demonstrate remarkable success in treating
hematological malignancies, but their effectiveness in non-hematopoietic cancers remains …

Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …

Immune checkpoint blockade has recently proven effective in subsets of patients with
esophageal adenocarcinoma (EAC) but little is known regarding the EAC immune …

Abstract The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly
affects the host respiratory system with~ 80% asymptomatic or mild cases and~ 5% severe …