Morbidly obese patients present with excess fatty tissue externally on the breast, neck,
thoracic wall and abdomen and internally in the mouth, pharynx and abdomen. This excess …

Propofol administered in conjunction with an opioid such as remifentanil is used to provide
total intravenous anesthesia for children. Drugs can be given as infusion controlled …

BACKGROUND In obese patients, the incidence of postoperative nausea and vomiting
(PONV) following sleeve gastrectomy under titration of total intravenous anaesthesia (TIVA) …

Pharmacokinetic simulations or TCI using pharmacokinetic models that account for the
influence of obesity on a drug's disposition are essential to predict plasma/effect-site …

Background The influence of obesity on the pharmacokinetic (PK) behavior of remifentanil is
incompletely understood. The aim of the current investigation was to develop a new …

Obesity is a widely used term, but may mean different things to different people–in the minds
of some people, an obese person is someone heavier than themselves. In the medical …

Purpose Anesthetic management of obese pediatric patients is challenging. With increasing
prevalence of childhood obesity, more severely obese children with comorbidities present …

Background Poor characterization of propofol pharmacokinetics and pharmacodynamics in
the morbidly obese (MO) pediatric population poses dosing challenges. This study was …

Background We used an automated bispectral index (BIS)-guided dual-loop controller to
determine propofol and remifentanil requirements during general anaesthesia in obese and …

Uncertainty exists as to the most suitable pharmacokinetic parameter sets for propofol target-
controlled infusions (TCI). The pharmacokinetic parameter sets currently employed are …