Aquaporins: highly regulated channels controlling plant water relations

F Chaumont, SD Tyerman - Plant physiology, 2014 - academic.oup.com
Plant growth and development are dependent on tight regulation of water movement. Water
diffusion across cell membranes is facilitated by aquaporins that provide plants with the …

Aquaporins: important but elusive drug targets

AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

Aquaporins: New players in breast cancer progression and treatment response

V Charlestin, D Fulkerson, CE Arias Matus… - Frontiers in …, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport
water and other small molecules and ions following an osmotic gradient across cell plasma …

Detecting aquaporin function and regulation

A Madeira, TF Moura, G Soveral - Frontiers in chemistry, 2016 - frontiersin.org
Water is the major component of cells and tissues throughout all forms of life. Fluxes of water
and solutes through cell membranes and epithelia are essential for osmoregulation and …

[图书][B] Aquaporin-targeted therapeutics: state-of-the-field

L Tradtrantip, BJ Jin, X Yao, MO Anderson… - 2017 - Springer
Drugs targeting aquaporins have broad potential clinical applications, including cancer,
obesity, edema, glaucoma, skin diseases and others. The astrocyte water channel …

Aquaglyceroporins: drug targets for metabolic diseases?

G Calamita, J Perret, C Delporte - Frontiers in physiology, 2018 - frontiersin.org
Aquaporins (AQPs) are a family of transmembrane channel proteins facilitating the transport
of water, small solutes, and gasses across biological membranes. AQPs are expressed in all …

[HTML][HTML] Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors

Y Sonntag, P Gena, A Maggio, T Singh, I Artner… - Journal of Biological …, 2019 - ASBMB
The aquaglyceroporins are a subfamily of aquaporins that conduct both water and glycerol.
Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption …

Aquaporin inhibitors

S Wang, EI Solenov, B Yang - Aquaporins, 2023 - Springer
Aquaporins (AQP) working as membrane channels facilitated water transport, play vital roles
in various physiological progress including cell migration, energy metabolism, inflammation …

Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition

F Baldini, P Portincasa, E Grasselli, G Damonte… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Hepatic steatosis is the hallmark of non-alcoholic fatty liver disease (NAFLD), the hepatic
manifestation of the metabolic syndrome and insulin resistance with potential evolution …

Challenges and achievements in the therapeutic modulation of aquaporin functionality

E Beitz, A Golldack, M Rothert, J von Buelow - Pharmacology & …, 2015 - Elsevier
Aquaporin (AQP) water and solute channels have basic physiological functions throughout
the human body. AQP-facilitated water permeability across cell membranes is required for …