Human neuroimaging research has transitioned from mapping local effects to developing
predictive models of mental events that integrate information distributed across multiple …

Life depends as much on the flow of information as on the flow of energy. Here we review
the many efforts to make this intuition precise. Starting with the building blocks of information …

The brain is a hugely diverse, heterogeneous structure. Whether or not heterogeneity at the
neural level plays a functional role remains unclear, and has been relatively little explored in …

Perception, cognition and behavior rely on flexible communication between microcircuits in
distinct cortical regions. The mechanisms underlying rapid information rerouting between …

Memories are believed to be encoded by sparse ensembles of neurons in the brain.
However, it remains unclear whether there is functional heterogeneity within individual …

Guiding behavior requires the brain to make predictions about the future values of sensory
inputs. Here, we show that efficient predictive computation starts at the earliest stages of the …

Although examples of variation and diversity exist throughout the nervous system, their
importance remains a source of debate. Even neurons of the same molecular type have …

Abstract Systems Biology and the Modern Synthesis are recent versions of two classical
biological paradigms that are known as structuralism and functionalism, or internalism and …

Objects and landmarks are crucial for guiding navigation and must be integrated into the
cognitive map of space. Studies of object coding in the hippocampus have primarily focused …

Anatomic connections between brain areas affect information flow between neuronal circuits
and the synchronization of neuronal activity. However, such structural connectivity does not …