Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …

The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

Neurotransmitters are biochemical molecules that transmit a signal from a neuron across the
synapse to a target cell, thus being essential to the function of the central and peripheral …

Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis …

Significant advances have been made uncovering the factors that render neurons
vulnerable in Parkinson's disease (PD). However, the critical pathogenic events leading to …

Parkinson disease (PD) is a chronic, progressive neurological disease that is associated
with a loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The …

Although Michael acceptors display a potent and broad spectrum of bioactivity, they have
largely been ignored in drug discovery because of their presumed indiscriminate reactivity …

There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …