Rationale for adjunctive treatment targeting multiple mechanisms in schizophrenia

BJ Kinon, S Leucht, C Tamminga, A Breier… - The Journal of …, 2024 - psychiatrist.com
Importance: Schizophrenia is a complex syndrome with taxing symptoms and for which
treatment challenges remain. Current dopamine D 2 receptor–blocking antipsychotics have …

Weight gain and metabolic changes in patients with first-episode psychosis or early-phase schizophrenia treated with olanzapine: a meta-analysis

CU Correll, M Højlund, C Graham… - International Journal …, 2023 - academic.oup.com
Background Patients with first-episode psychosis or early-phase schizophrenia are
susceptible to olanzapine-associated weight gain and cardiometabolic dysregulation. This …

Sexual dysfunction in schizophrenia: a systematic review and meta-analysis

T Korchia, V Achour, M Faugere, A Albeash… - JAMA …, 2023 - jamanetwork.com
Importance In individuals with schizophrenia, antipsychotic-induced dysfunctions are
frequent but often underexplored in clinical practice. Objective To synthetize the data of …

An analysis of views about supported reduction or discontinuation of antipsychotic treatment among people with schizophrenia and other psychotic disorders

NE Crellin, S Priebe, N Morant, G Lewis, N Freemantle… - BMC psychiatry, 2022 - Springer
Background Antipsychotic medication can reduce psychotic symptoms and risk of relapse in
people with schizophrenia and related disorders, but it is not always effective and adverse …

Weight gain and comorbidities associated with oral second-generation antipsychotics: analysis of real-world data for patients with schizophrenia or bipolar I disorder

MJ Doane, L Bessonova, HS Friedler, KM Mortimer… - BMC psychiatry, 2022 - Springer
Background Many second-generation antipsychotics (SGAs) are associated with weight
gain and cardiometabolic effects. Antipsychotic-associated weight gain is linked to treatment …

A new treatment paradigm: targeting trace amine-associated receptor 1 (TAAR1) in schizophrenia

JM Kane - Journal of Clinical Psychopharmacology, 2022 - journals.lww.com
This continuing education supplement is jointly provided by Medical Education Resources
and CMEology. The supplement is supported by an independent educational grant from …

The impact of weight gain on antipsychotic nonadherence or discontinuation: A systematic review and meta‐analysis

R De, ECC Smith, J Navagnanavel, E Au… - Acta Psychiatrica …, 2024 - Wiley Online Library
Background Nonadherence/discontinuation of antipsychotic (AP) medications represents an
important clinical issue in patients across psychiatric disorders, including schizophrenia …

The role of pharmacists in supporting service users to optimise antipsychotic medication

J Howe, L Lindsey - International Journal of Clinical Pharmacy, 2023 - Springer
Pharmacists have a contribution to make in improving optimising medication use for people
on antipsychotic medication. The rates of prescribing antipsychotics have increased in …

Unmet needs with antipsychotic treatment in schizophrenia and bipolar I disorder: patient perspectives from qualitative focus groups

MJ Doane, K Raymond, C Saucier, L Bessonova… - BMC psychiatry, 2023 - Springer
Background Schizophrenia (SZ) and bipolar I disorder (BD-I) are chronic mental health
disorders often treated with antipsychotic medications. This qualitative study sought to better …

Aripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU): review of its possible role in schizophrenia therapy

BT Baune - Current Medical Research and Opinion, 2024 - Taylor & Francis
Most patients with schizophrenia need life-long treatment. There is therefore a continued
need for effective and tolerable treatment options. A 2-monthly LAI formulation of …