Small-molecule drug discovery can be viewed as a challenging multidimensional problem in
which various characteristics of compounds—including efficacy, pharmacokinetics and …

We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …

Sharpless and co‐workers previously studied the [2σ+ 2σ+ 2π] cycloaddition of diethyl
azodicarboxylate (DEAD) and quadricyclane and reported that the addition of water to the …

Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has
been synthesized using continuous flow methodology. Desorption electrospray ionization …

We demonstrate the use of accelerated reactions with desorption electrospray ionization
mass spectrometry (DESI-MS) as a tool for predicting the outcome of microfluidic reactions …

Suzuki cross-coupling is a widely performed reaction, typically using metal catalysts under
heated conditions. Acceleration of the Suzuki cross-coupling reaction has been previously …

Nucleophilic aromatic substitution (SNAr) reactions were optimized using high-throughput
experimentation techniques for execution under flow conditions. A total of 3072 unique …

Traditional methods to discover optimal reaction conditions for small molecule synthesis is a
time‐consuming effort that requires large quantities of material and a significant expenditure …

Desorption electrospray ionization-mass spectrometry (DESI-MS) was used as a high-
throughput experimentation (HTE) tool to rapidly identify derivatives of the biobased platform …

Electrospray (ES) and paper spray (PS) mass spectrometry were used to create confined
liquid volumes in which accelerated air and water sensitive, heterogeneous, copper …