Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
Signaling inflammation across the gut-brain axis
G Agirman, KB Yu, EY Hsiao - Science, 2021 - science.org
The brain and gastrointestinal tract are critical sensory organs responsible for detecting,
relaying, integrating, and responding to signals derived from the internal and external …
relaying, integrating, and responding to signals derived from the internal and external …
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration
Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …
macrophages, and recruited monocyte-derived cells; together, they control brain …
Emerging roles of innate and adaptive immunity in Alzheimer's disease
X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …
Microglia: Immune and non-immune functions
K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …
with diverse functions essential to the developing and adult brain during homeostasis and …
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
Macrophages are important players in the maintenance of tissue homeostasis. Perivascular
and leptomeningeal macrophages reside near the central nervous system (CNS) …
and leptomeningeal macrophages reside near the central nervous system (CNS) …
Specification of CNS macrophage subsets occurs postnatally in defined niches
All tissue-resident macrophages of the central nervous system (CNS)—including
parenchymal microglia, as well as CNS-associated macrophages (CAMs) such as …
parenchymal microglia, as well as CNS-associated macrophages (CAMs) such as …
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …
immune functions. The diverse role of myeloid populations, including monocytes …
Transforming the understanding of brain immunity
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …