Role of neuroinflammation in neurodegeneration development

W Zhang, D Xiao, Q Mao, H Xia - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Signaling inflammation across the gut-brain axis

G Agirman, KB Yu, EY Hsiao - Science, 2021 - science.org
The brain and gastrointestinal tract are critical sensory organs responsible for detecting,
relaying, integrating, and responding to signals derived from the internal and external …

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

X Chen, M Firulyova, M Manis, J Herz, I Smirnov… - Nature, 2023 - nature.com
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

A Silvin, S Uderhardt, C Piot, S Da Mesquita, K Yang… - Immunity, 2022 - cell.com
Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …

Emerging roles of innate and adaptive immunity in Alzheimer's disease

X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Microglia: Immune and non-immune functions

K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

A Drieu, S Du, SE Storck, J Rustenhoven… - Nature, 2022 - nature.com
Macrophages are important players in the maintenance of tissue homeostasis. Perivascular
and leptomeningeal macrophages reside near the central nervous system (CNS) …

Specification of CNS macrophage subsets occurs postnatally in defined niches

T Masuda, L Amann, G Monaco, R Sankowski… - Nature, 2022 - nature.com
All tissue-resident macrophages of the central nervous system (CNS)—including
parenchymal microglia, as well as CNS-associated macrophages (CAMs) such as …

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

A Cugurra, T Mamuladze, J Rustenhoven, T Dykstra… - Science, 2021 - science.org
INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

Transforming the understanding of brain immunity

G Castellani, T Croese, JM Peralta Ramos, M Schwartz - Science, 2023 - science.org
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …