Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for
cancer initiation, progression, and invasion. This multistage process is based on a dense …

The traditional structure to function paradigm conceives of a protein's function as emerging
from its structure. In recent years, it has been established that unstructured, intrinsically …

Membrane contact sites (MCS) are intracellular regions where two organelles come closer
to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS …

The endoplasmic reticulum (ER), the most pervasive organelle, exchanges information and
material with many other organelles, but the extent of its interorganelle connections and the …

Motivation: Proteins often recognize their interaction partners on the basis of short linear
motifs located in disordered regions on proteins' surface. Experimental techniques that study …

Abstract Knowledge of the detailed structure of macromolecular interactions is key to a better
understanding and modulation of essential cellular functions and pathological situations …

Linear motifs (LMs), used by a subset of all protein–protein interactions (PPIs), bind to
globular receptors or domains and play an important role in signaling networks. LMPID …

Posttranslational regulation of protein function is an ubiquitous mechanism in eukaryotic
cells. Here, we analyzed biological properties of nodes and edges of a human protein …

Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of
motif classes including thousands of motif instances are known. Our theory estimates how …

Shewanella oneidensis MR-1 is capable of extracellular electron transfer (EET) and hence
has attracted considerable attention. The EET pathways mainly consist of c-type …