Despite the considerable progress in strategies of myocardial protection, ischemic heart
diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality …

Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs)
are key in orchestrating responses to environmental stressors. We have previously identified …

Urocortin 2, an endogenous selective ligand for the corticotropin-releasing hormone
receptor type 2, has been suggested to exert cardioprotective effects. We analyzed the …

Middle-aged obesity and aging cachexia present healthcare challenges. Central
responsiveness to body-weight-reducing mediators, eg, to leptin, changes during aging in a …

The corticotropin-releasing factor neuropeptides (CRH and UCN-1, 2, 3), as well as spexin,
contribute to the control of energy balance and limit food intake in mammals. However, the …

Ao meu Orientador, Prof. Doutor Paulo Castro Chaves, dirijo o primeiro agradecimento.
Acompanhou-me desde os primeiros passos na Medicina e ao longo de todo o meu …