One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

The enteric nervous system (ENS) is an extensive network comprising millions of neurons
and glial cells contained within the wall of the gastrointestinal tract. The major functions of …

Endothelial cells transduce mechanical forces from blood flow into intracellular signals
required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to …

Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the
gastrointestinal tract, but the signaling processes that link immune activation with visceral …

Inflammation in the intestines causes abdominal pain that is challenging to manage. The
terminals of sensory neurons innervating the gut are surrounded by glia. Here, using a …

Glia in the central nervous system exert precise spatial and temporal regulation over neural
circuitry on a synapse-specific basis, but it is unclear if peripheral glia share this exquisite …

Stem cell therapies for nervous system disorders are hindered by a lack of accessible
autologous sources of neural stem cells (NSCs). In this study, neural crest–derived Schwann …

Simple Summary Connexin hemichannels are formed by connexin protein family members,
and connect cytosol and extracellular milium. The function of connexin hemichannels cannot …

Background & Aims Tachykinins are involved in physiological and pathophysiological
mechanisms in the gastrointestinal tract. The major sources of tachykinins in the gut are …

Enteric glia are a unique population of peripheral neuroglia that regulate homeostasis in the
enteric nervous system (ENS) and intestinal functions. Despite existing in functionally …