A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

The clinical outcome of patients with a diagnosis of hormone receptor (HR)+ breast cancer
has improved remarkably since the arrival of endocrine therapy. Yet, resistance to standard …

We established previously that X-linked inhibitor of apoptosis protein (Xiap) is a determinant
of cisplatin (CDDP) resistance in human ovarian cancer cells and that down-regulation of …

Nod2 is an intracellular sensor of a specific bacterial cell wall component, muramyl
dipeptide, and activation of Nod2 stimulates an inflammatory response. Specific mutations of …

Cancer cells must alter their metabolism in order to satisfy the demands of necessary energy
and cellular building blocks. These metabolic alterations are mediated by many oncogenic …

The sigma-2 receptor was originally defined pharmacologically and recently identified as
TMEM97. TMEM97 has been validated as a biomarker of proliferative status and the …

Abstract The Polo-like kinases (Plks) are a highly conserved family of protein kinases that
function in regulation of cell cycle and DNA damage-induced checkpoints. Evidence of a …

Loss of OVCA1/DPH2L1 correlates with ovarian and breast cancer. To study its in vivo role,
we generated Ovca1 mutant alleles in mice. Ovca1 heterozygotes spontaneously develop …

The cytokine TGF-β acts as a tumor suppressor in normal epithelial cells and during the
early stages of tumorigenesis. During malignant progression, cancer cells can switch their …

Membrane proteins play a central role in the interaction of the cell with its environment and
in the function of subcellular organelles. The current study focused on developing a better …