The rapid growth of obesity worldwide has made it a major health problem, while the
dramatic increase in the prevalence of obesity has had a significant impact on the …

Chronic kidney disease is highly prevalent worldwide. The decline of renal function is
associated with inadequate removal of a variety of uremic toxins that exert detrimental …

Diurnal rhythms influence cardiovascular physiology, ie heart rate and blood pressure, and
they appear to also modulate the incidence of serious adverse cardiac events. Diurnal …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …

The experimental data obtained from both human and rodent studies suggest that melatonin
may have utility in the treatment of several cardiovascular conditions. In particular …

Obstructive sleep apnea (OSA) associated with chronic intermittent hypoxia (CIH) increases
the morbidity and mortality of ischemic heart disease in patients. Yet, there is a paucity of …

Aging is a complex and progressive process that involves physiological and metabolic
deterioration in every organ and system. Cardiovascular diseases are one of the most …

Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure,
which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological …

Nitric oxide (NO) deficiency is associated with development of hypertension. We examined
whether melatonin protects against the blood pressure increase is because of the …