Cell-division control affects many aspects of development. Caenorhabditis elegans cell-
cycle genes have been identified over the past decade, including at least two distinct Cyclin …

During animal development, a single fertilized egg forms a complete organism with tens to
trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore …

In Drosophila, the posterior determinant nanos is required for embryonic patterning and for
primordial germ cell (PGC) development. We have identified three genes in Caenorhabditis …

Innate immunity is an ancient and conserved defense mechanism. Although host responses
toward various pathogens have been delineated, how these responses are orchestrated in a …

The Polo‐like kinases are key regulatory molecules required during the cell cycle for the
successful completion of mitosis. We have cloned a C. elegans homolog of the Drosophila …

Background The SCF ubiquitin-ligase complex targets the ubiquitin-mediated degradation of
proteins in multiple dynamic cellular processes. A key SCF component is the Skp1 protein …

In many animals, oocytes enter meiosis early in their development but arrest in meiotic
prophase I. Oocyte growth, which occurs during this arrest period, enables the acquisition of …

As a fundamental process of development, cell proliferation must be coordinated with other
processes such as fate differentiation. Through statistical analysis of individual cell cycle …

Cell cycle lengths vary widely among different cells within an animal, yet mechanisms of cell
cycle length regulation are poorly understood. In the Caenorhabditis elegans embryo, the …

Polarization of the one-cell C. elegans embryo establishes the animal's anterior-posterior
(ap) axis. We have identified reduction-of-function anaphase-promoting complex (APC) …