NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of
citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic …

Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …

Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …

Metabolic pathways are now well recognized as important regulators of immune
differentiation and activation, and thus influence the development of autoimmune diseases …

Abstract The small RhoGTPase Rac1 is implicated in a variety of events related to actin
cytoskeleton rearrangement. Remarkably, another event that is completely different from …

Primary immunodeficiencies affecting the function of neutrophils and other phagocytic
leukocytes are notable for an increased susceptibility to bacterial and fungal infections as a …

The phagocyte reduced NAD phosphate (NADPH) oxidase generates superoxide, the
precursor to reactive oxygen species (ROS) that has both antimicrobial and …

Abstract Coronavirus disease 2019 (COVID‐19) is a systemic inflammatory condition with
high mortality that may benefit from personalized medicine and high‐precision approaches …

A single nucleotide polymorphism in Ncf1 has been found with a major effect on chronic
inflammatory autoimmune diseases in the rat with the surprising observation that a lower …

Genome-wide association studies have identified risk loci for SLE, but a large proportion of
the genetic contribution to SLE still remains unexplained. To detect novel risk genes, and to …