Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …

Period (PER) protein phosphorylation is a critical regulator of circadian period, yet an
integrated understanding of the role and interaction between phosphorylation sites that can …

Circadian clocks are cell-autonomous timing mechanisms that organize cell functions in a
24-h periodicity. In mammals, the main circadian oscillator consists of transcription …

The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in
response to the changing environment. While food is a known zeitgeber for clocks in …

The alignment of fasting and feeding with the sleep/wake cycle is coordinated by
hypothalamic neurons, though the underlying molecular programs remain incompletely …

Heterogeneous ribonucleoproteins (hnRNPs) are RNA binding molecules that are involved
in key processes such as RNA splicing and transcription. One such hnRNP protein, hnRNP …

The core body temperature of all mammals oscillates with the time of the day. However,
direct molecular consequences of small, physiological changes in body temperature remain …

The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …