New therapeutic strategies have emerged along with our understanding that disturbances of
iron homeostasis, impaired proliferation of erythroid progenitor cells, and blunted …

Background: Perioperative anemia has been associated with increased risk of red blood cell
transfusion and increased morbidity and mortality after surgery. The optimal approach to the …

Hip fracture is a leading cause of profound morbidity in individuals aged 65 years and older,
ranking in the top 10 causes of loss of disability-adjusted life-years for older adults …

Previously undiagnosed anaemia is common in elective orthopaedic surgical patients and is
associated with increased likelihood of blood transfusion and increased perioperative …

BACKGROUND: A minority of patients having cardiac procedures (15% to 20%) consume
more than 80% of the blood products transfused at operation. Blood must be viewed as a …

While complex physiological mechanisms exist to regulate and optimize tissue oxygenation
under various conditions, clinical and experimental evidence indicates that anaemia …

Objectives: To date, there are no published guidelines to direct RBC transfusion decision-
making specifically for critically ill children. We present the recommendations from the …

Background: Several studies have indicated that a restrictive erythrocyte transfusion strategy
is as safe as a liberal one in critically ill patients, but there is no clear evidence to support the …

Recent progress has been made in the identification and implementation of best transfusion
practices on the basis of evidence-based clinical trials, published clinical practice …

Our aim was to determine the total blood loss associated with surgery for fracture of the hip
and to identify risk factors for increased blood loss. We prospectively studied 546 patients …